Journal article
Measurement of the 3D arterial wall strain tensor using intravascular B-mode ultrasound images: a feasibility study
Physics in medicine & biology, v 55(21), pp 6377-6394
07 Nov 2010
PMID: 20938066
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intravascular ultrasound (IVUS) elastography is a promising tool for studying atherosclerotic plaque composition and assessing plaque vulnerability. Current IVUS elastography techniques can measure the 1D or 2D strain of the vessel wall using various motion tracking algorithms. Since biological soft tissue tends to deform non-uniformly in 3D, measurement of the complete 3D strain tensor is desirable for more rigorous analysis of arterial wall mechanics. In this paper, we extend our previously developed method of 2D arterial wall strain measurement based on non-rigid image registration into 3D strain measurement. The new technique registers two image volumes acquired from the same vessel segment under different levels of luminal pressure and longitudinal stress. The 3D displacement field obtained from the image registration is used to calculate the local 3D strain tensor. From the 3D strain tensor, radial, circumferential and longitudinal strain distributions can be obtained and displayed. This strain tensor measurement method is validated and evaluated using IVUS images of healthy porcine carotid arteries subjected to a luminal pressure increase and longitudinal stretch. The ability of the algorithm to overcome systematic noise was tested, as well as the consistency of the results under different longitudinal frame resolutions.
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Details
- Title
- Measurement of the 3D arterial wall strain tensor using intravascular B-mode ultrasound images: a feasibility study
- Creators
- Yun Liang - Duke UniversityHui Zhu - Duke UniversityMorton H. Friedman - Duke University
- Publication Details
- Physics in medicine & biology, v 55(21), pp 6377-6394
- Publisher
- Iop Publishing Ltd
- Number of pages
- 18
- Grant note
- R01HL058856 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) HL058856 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000283056000006
- Scopus ID
- 2-s2.0-78149383886
- Other Identifier
- 991021897322804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Radiology, Nuclear Medicine & Medical Imaging