Journal article
Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation
Journal of the mechanical behavior of biomedical materials, v 4(1), pp 34-43
Jan 2011
PMID: 21094478
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study demonstrates a novel approach to characterizing hydrated bone’s viscoelastic behavior at the lamellar length scales using dynamic indentation techniques. We studied the submicron-level viscoelastic response of bone tissue from two different inbred mouse strains, A/J and B6, with known differences in whole bone and tissue-level mechanical properties. Our results show that bone having a higher collagen content or a lower mineral-to-matrix ratio demonstrates a trend towards a larger viscoelastic response. When normalized for anatomical location relative to biological growth patterns in the antero-medial (AM) cortex, bone tissue from B6 femora, known to have a lower mineral-to-matrix ratio, is shown to exhibit a significantly higher viscoelastic response compared to A/J tissue. Newer bone regions with a higher collagen content (closer to the endosteal edge of the AM cortex) showed a trend towards a larger viscoelastic response. Our study demonstrates the feasibility of this technique to be used to study local composition-property relationships in bone. Further, this technique of viscoelastic nanoindentation mapping of the bone surface at these submicron length scales is shown to be highly advantageous in studying sub-surface features, such as porosity, of wet hydrated biological specimens, which are difficult to identify using other methods.
Metrics
Details
- Title
- Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation
- Creators
- Siddhartha Pathak - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USAJ. Gregory Swadener - Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA and Engineering Systems & Management, Aston University, Aston Triangle, Birmingham B4 7ET, UKSurya R Kalidindi - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USAHayden-William Courtland - Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, New York, NY 10029Karl J Jepsen - Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 10029Haviva M Goldman - Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
- Publication Details
- Journal of the mechanical behavior of biomedical materials, v 4(1), pp 34-43
- Publisher
- Elsevier
- Grant note
- R01 AR044927-09 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000286126400005
- Scopus ID
- 2-s2.0-78649316453
- Other Identifier
- 991014878113404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials