Journal article
Mechanical and geometrical determinants of wall stress in abdominal aortic aneurysms: A computational study
PloS one, v 13(2), pp e0192032-e0192032
05 Feb 2018
PMID: 29401512
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An aortic aneurysm (AA) is a focal dilatation of the aortic wall. Occurrence of AA rupture is an all too common event that is associated with high levels of patient morbidity and mortality. The decision to surgically intervene prior to AA rupture is made with recognition of significant procedural risks, and is primarily based on the maximal diameter and/or growth rate of the AA. Despite established thresholds for intervention, rupture occurs in a notable subset of patients exhibiting sub-critical maximal diameters and/or growth rates. Therefore, a pressing need remains to identify better predictors of rupture risk and ultimately integrate their measurement into clinical decision making. In this study, we use a series of finite element-based computational models that represent a range of plausible AA scenarios, and evaluate the relative sensitivity of wall stress to geometrical and mechanical properties of the aneurysmal tissue. Taken together, our findings encourage an expansion of geometrical parameters considered for rupture risk assessment, and provide perspective on the degree to which tissue mechanical properties may modulate peak stress values within aneurysmal tissue.
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Details
- Title
- Mechanical and geometrical determinants of wall stress in abdominal aortic aneurysms: A computational study
- Creators
- Dara Azar - University of South CarolinaDonya Ohadi - University of South CarolinaAlexander Rachev - University of South CarolinaJohn F. Eberth - University of South CarolinaMark J. Uline - University of South CarolinaTarek Shazly - University of South Carolina
- Publication Details
- PloS one, v 13(2), pp e0192032-e0192032
- Publisher
- Public Library Science
- Number of pages
- 15
- Grant note
- P20GM103499; R01HL133662 / NIH INBRE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P20GM103499 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000424101400031
- Scopus ID
- 2-s2.0-85041383095
- Other Identifier
- 991021902499504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Peripheral Vascular Disease