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Mechanical evaluation of poly(vinyl alcohol)-based fibrous composites as biomaterials for meniscal tissue replacement
Journal article   Peer reviewed

Mechanical evaluation of poly(vinyl alcohol)-based fibrous composites as biomaterials for meniscal tissue replacement

Julianne L Holloway, Anthony M Lowman and Giuseppe R Palmese
Acta biomaterialia, v 6(12), pp 4716-4724
Dec 2010
DOI: https://doi.org/10.1016/j.actbio.2010.06.025
PMID: 20601243
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Polyvinyl Alcohol - chemistry Molecular Weight Tissue Engineering - methods Biocompatible Materials - chemistry Cross-Linking Reagents - pharmacology Humans Menisci, Tibial - drug effects Stress, Mechanical Tensile Strength - drug effects Biocompatible Materials - pharmacology Tissue Scaffolds - chemistry Materials Testing - methods Menisci, Tibial - physiology Water - chemistry Mechanical Phenomena Porosity - drug effects Polyethylenes - chemistry Hydrogels - chemistry
In this study, poly(vinyl alcohol) (PVA) hydrogels were reinforced with ultrahigh molecular weight polyethylene (UHMWPE) and PP fibers and evaluated as potential nondegradable meniscal replacements. An investigation of hydrogel and composite mechanical properties indicates that fiber-reinforced PVA hydrogels could replicate the unique anisotropic modulus distribution present in the native meniscus; the most commonly damaged orthopedic tissue. More specifically, fibrous reinforcement successfully increased the tensile modulus of the biomaterial from 0.23±0.02MPa without any reinforcement to 258.1±40.1MPa at 29vol.% UHMWPE. Additionally, the molecular weight between cross-links, bound water and the microstructure of the PVA hydrogels were evaluated as a function of freeze-thaw cycles and polymer concentration to lend insight into the processes occurring during synthesis. These results suggest the presence of multiple mechanisms as causes for increasing hydrogel modulus with freeze-thaw cycling, including hydrogen bonding between amorphous and/or crystalline regions, and the formation of highly concentrated regions of mostly amorphous PVA chains. It is possible that the formation of regions with highly concentrated amounts of PVA increases the load-bearing ability of the hydrogels.

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Web of Science research areas
Engineering, Biomedical
Materials Science, Biomaterials
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