Journal article
Mechanical force modulates beta-catenin intracellular signaling activity
Annals of biomedical engineering, Vol.28(SUPPL. 1), pp.S-75
01 Jan 2000
Abstract
Beta-catenin is a key signal transduction protein in the wnt signaling pathway that controls embryonic body patterning and cancer. Beta-catenin signaling activity in colon and breast carcinoma cells was examined to study the effect of shear stress. Beta-catenin signaling activity decreased as exposure to shear flow increased in time from 0,3,6, and 12 hrs. Transfection of cells with dominant-negative kinases (IKKs) reversed the shear stress-induced decrease in beta-catenin signaling activity.
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Details
- Title
- Mechanical force modulates beta-catenin intracellular signaling activity
- Creators
- Chris AvvisatoAydin TozerenStephen Byers
- Publication Details
- Annals of biomedical engineering, Vol.28(SUPPL. 1), pp.S-75
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Identifiers
- 991021895785204721