Journal article
Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering
Biomaterials, v 33(20), pp 5067-5075
Jul 2012
PMID: 22494891
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Multifunctional bone scaffold materials have been produced from a biodegradable polymer, poly(l-lactic acid) (PLLA), and 1–10% wt of octadecylamine-functionalized nanodiamond (ND-ODA) via solution casting followed by compression molding. By comparison to pure PLLA, the addition of 10% wt of ND-ODA resulted in a significant improvement of the mechanical properties of the composite matrix, including a 280% increase in the strain at failure and a 310% increase in fracture energy in tensile tests. The biomimetic process of bonelike apatite growth on the ND-ODA/PLLA scaffolds was studied using microscopic and spectroscopic techniques. The enhanced mechanical properties and the increased mineralization capability with higher ND-ODA concentration suggest that these biodegradable composites may potentially be useful for a variety of biomedical applications, including scaffolds for orthopedic regenerative engineering.
Metrics
Details
- Title
- Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering
- Creators
- Qingwei Zhang - Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut St., Philadelphia, PA 19104, USAVadym N Mochalin - Department of Materials Science and Engineering, A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA 19104, USAIoannis Neitzel - Department of Materials Science and Engineering, A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA 19104, USAKavan Hazeli - Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut St., Philadelphia, PA 19104, USAJunjie Niu - Department of Materials Science and Engineering, A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA 19104, USAAntonios Kontsos - Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut St., Philadelphia, PA 19104, USAJack G Zhou - Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut St., Philadelphia, PA 19104, USAPeter I Lelkes - Department of Bioengineering, Temple University, 1147 N 12th Street, Philadelphia, PA 19122, USAYury Gogotsi - Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut St., Philadelphia, PA 19104, USA
- Publication Details
- Biomaterials, v 33(20), pp 5067-5075
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000304502900010
- Scopus ID
- 2-s2.0-84860376039
- Other Identifier
- 991014877700004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials