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Journal article
Mechanical properties of -tricalcium phosphate-based bone cements incorporating regenerative biomaterials for filling bone defects exposed to low mechanical loads
Journal of biomedical materials research. Part B, Applied biomaterials, v 104(1), pp 149-157
01 Jan 2016
PMID: 25677680
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Calcium phosphate-based cements with enhanced regenerative potential are promising biomaterials for the healing of bone defects in procedures such as percutaneous vertebroplasty. With a view to the use of such cements for low load bearing applications such as sinus augmentation or filling extraction sites. However, the inclusion of certain species into bone cement formulations has the potential to diminish the mechanical properties of the formulations and thereby reduce their prospects for clinical translation. Consequently, we have prepared -tricalcium phosphate (-TCP)-based bone cements including materials that we would expect to improve their regenerative potential, and describe the mechanical properties of the resulting formulations herein. Formulations incorporated -TCP, hydroxyapatite, biopolymer-thickened wetting agents, sutures, and platelet poor plasma. The mechanical properties of the composites were composition dependent, and optimized formulations had clinically relevant mechanical properties. Such calcium phosphate-based cements have potential as replacements for cements such as those based on polymethylmethacrylate. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 149-157, 2016.
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Details
- Title
- Mechanical properties of -tricalcium phosphate-based bone cements incorporating regenerative biomaterials for filling bone defects exposed to low mechanical loads
- Creators
- Reed Harrison - The University of Texas at AustinZachary K. Criss - The University of Texas at AustinLacie Feller - The University of Texas at AustinShan P. Modi - The University of Texas at AustinJohn G. Hardy - The University of Texas at AustinChristine E. Schmidt - The University of Texas at AustinLaura J. Suggs - The University of Texas at AustinMatthew B. Murphy - The University of Texas at Austin
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, v 104(1), pp 149-157
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- 0741973 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery; Emergency Medicine
- Web of Science ID
- WOS:000367340000018
- Scopus ID
- 2-s2.0-84952872171
- Other Identifier
- 991022008088704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials