Logo image
Back
Mechanical properties of human fetal talus
Journal article   Open access   Peer reviewed

Mechanical properties of human fetal talus

Roza Mahmoodian, Jeremi Leasure, Hemanth Gadikota, Franco Capaldi and Sorin Siegler
Clinical orthopaedics and related research, v 467(5), pp 1186-1194
May 2009
DOI: https://doi.org/10.1007/s11999-008-0693-6
PMID: 19142689
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1007/s11999-008-0693-6View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Biomechanical Phenomena Cartilage, Articular - embryology Cartilage, Articular - physiopathology Casts, Surgical Clubfoot - embryology Clubfoot - physiopathology Clubfoot - therapy Combined Modality Therapy Elastic Modulus Female Gestational Age Humans Minimally Invasive Surgical Procedures Models, Biological Musculoskeletal Manipulations Orthopedic Procedures Osteogenesis Permeability Poisson Distribution Pregnancy Pregnancy Trimester, Third Stress, Mechanical Talus - embryology Talus - physiopathology
Mechanical characterization of human cartilage anlagen is required to effectively model congenital musculoskeletal deformities. Such modeling can effectively explore the effect of treatment procedures and potentially suggest enhanced treatment methods. Using serial MRI, we have noted shape changes of the cartilaginous hindfoot anlagen in patients with clubfoot, suggesting they are soft and deformable. We therefore determined the stress relaxation behavior of cartilage plugs obtained from third-trimester stillborn fetuses in unconfined and confined compression geometries. The material parameters determined were the aggregate modulus H(A) = 0.15 +/- 0.07 MPa, Poisson's ratio nu = 0.4 +/- 0.06, Young's modulus E(s) = 0.06 +/- 0.03 MPa, and permeability coefficients k(0) = 2.01 +/- 0.8 x 10(-14) m(4) N(-1) s(-1) and M = 4.6 +/- 1.0. As compared with adult articular cartilage, stiffness was an order of magnitude lower than the values reported in the literature, suggesting the relative softness of the tissue, and the permeability was an order of magnitude higher, indicating relative ease of flow in the tissue. Poisson's ratio also was close to the higher end of the range reported in previous studies. Such material is expected to deform and relax to larger extents. These findings are consistent with the deformability of the cartilage anlagen during manipulation and casting for treatment of clubfoot.

Metrics

6 Record Views
9 citations in Web of Science
11 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Web of Science research areas
Orthopedics
Surgery
Logo image