Journal article
Mechanical study of polycaprolactone-hydroxyapatite porous scaffolds created by porogen-based solid freeform fabrication method
Journal of applied biomaterials & functional materials, v 12(3), pp 145-154
01 Jan 2014
PMID: 24425377
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Materials and Methods: Polycaprolactone (PCL) and polycaprolactone-hydroxyapatite (PCL-HA) scaffolds with 600-mu m pore size were fabricated by drop-on-demand printing (DDP) structured porogen method followed with injection molding. Specimens with special dimensions of 4.2x4.2x5.4 mm(3) and 6.6x6.6x13.8 mm(3) were designed and fabricated for compression and tensile tests, respectively. The mechanical study was performed on both solid and porous PCL and PCL-HA samples. The effect on mechanical properties of the HA content ratio in PCL-HA composites was investigated.
Results: Porous scaffold made of 80/20 PCL-HA composite had an ultimate compressive strength of 3.7 +/- 0.2 MPa and compression modulus of 61.4 +/- 3.4 MPa, which is in the range of reported trabecular bone's compressive strength. Increasing the concentration of HA in the composites raised compressive properties and stiffness significantly (P<0.05), which demonstrates that PCL-HA composites have the potential for application in bone regeneration. Tensile test of solid PCL and PCL-HA composites showed that the ultimate tensile strength and tensile modulus increased with increases of the concentration of HA in the composites. The tensile test was also conducted on PCL porous scaffold; the result indicated that the scaffold was slightly softer and weaker in tension compared with compression.
Conclusions: Combining compression and tensile test results, our study may guide the possible application of these biomaterials in bone tissue engineering and support further development of microstructure-based models of scaffold mechanical properties.
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Details
- Title
- Mechanical study of polycaprolactone-hydroxyapatite porous scaffolds created by porogen-based solid freeform fabrication method
- Creators
- Lin Lu - Drexel UniversityQingwei Zhang - Drexel UniversityDavid M. Wootton - Cooper UnionRichard Chiou - Drexel UniversityDichen Li - Xi'an Jiaotong UniversityBingheng Lu - Xi'an Jiaotong UniversityPeter I. Lelkes - Temple UniversityJack Zhou - Drexel University
- Publication Details
- Journal of applied biomaterials & functional materials, v 12(3), pp 145-154
- Publisher
- Sage
- Number of pages
- 10
- Grant note
- Surgical Engineering Enterprise of the Drexel College of Medicine Strategic Initiative DMI-0300405; CMMI-0700139; CMMI-0925348 / National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Engineering Technology; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000347554200005
- Scopus ID
- 2-s2.0-84925343148
- Other Identifier
- 991019168114704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical
- Materials Science, Biomaterials