Journal article
Mechanisms of Platelet Dysfunction and Response to DDAVP in Patients with Congenital Platelet Function Defects: A Double-Blind Placebo-Controlled Trial
Thrombosis and haemostasis, v 74(4), pp 1071-1078
1995
PMID: 8560416
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Summary
To examine the impact of the underlying defective platelet mechanism on the response to 1-desamino-8-D-arginine vasopressin (DDAVP, Desmopressin), we studied the effect of intravenous infusion of 0.3 μg/kg of DDAVP in a randomized double blind placebo-controlled trial with cross-over in 18 carefully characterized patients with congenital platelet defects (CPD) and BT ≥9 min. Eleven patients had normal dense granule stores and normal thromboxane A2 (TxA2) production (Group I), 3 patients had normal granule stores but impaired TxA2 production (Group II), and 4 had δ-storage pool deficiency (Group III). DDAVP shortened BT at 50 min (DDAVP 14.6 ± 2.2 vs placebo 19.6 ± 2.3 min; n = 18; mean ± SE; p = 0.003) and 4h (17.0 ± 2.2 vs 19.6 ±2.1 min, p = 0.055), and raised plasma FVIIIC and von Willebrand factor (vWF). At 50 min DDAVP shortened BT by ≥5 min in 8 of 11 Group I patients (mean 9.7 ± 1.3 vs 16.3 ± 2.8 min; p <0.008), 1 of 3 Group II patients (11.9 ± 3.9 vs 17.7 ± 6.6; p = NS) and none of Group III patients (mean 30 min both arms). Ten patients (Group I or II) were managed successfully during surgical procedures with DDAVP alone. We conclude that DDAVP shortens BT in majority of CPD patients with normal dense granule stores and suggest that BT response may be dependent on the underlying platelet defect. DDAVP is a useful modality in management of selected patients, particularly those with normal dense granule stores.
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Details
- Title
- Mechanisms of Platelet Dysfunction and Response to DDAVP in Patients with Congenital Platelet Function Defects
- Creators
- A Koneti Rao - Temple UniversitySikha Ghosh - Temple UniversityLing Sun - Temple UniversityXu Yang - Temple UniversityJyoti Disa - Temple UniversityPeter Pickens - Abington Memorial HospitalMarcia Polansky - Hahnemann University Hospital
- Publication Details
- Thrombosis and haemostasis, v 74(4), pp 1071-1078
- Publisher
- Thieme
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1995TA95100017
- Scopus ID
- 2-s2.0-0028823343
- Other Identifier
- 991019184296804721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology
- Peripheral Vascular Disease