Journal article
Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity
Nature communications, v 13(1), pp 1386-1386
16 Mar 2022
PMID: 35296648
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation of medial PFC (mPFC) neurons in mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation of mPFC neurons in downstream regions, including the anteromedial thalamic nucleus (AM), reinforced behavior and activated midbrain dopaminergic neurons. The stimulation of AM neurons projecting to the mPFC also reinforced behavior and activated dopamine neurons, and mPFC and AM showed a positive-feedback loop organization. We also found using fMRI in human participants watching reinforcing video clips that there is reciprocal excitatory functional connectivity, as well as co-activation of the two regions. Our results suggest that this cortico-thalamic loop regulates motivation, reinforcement, and dopaminergic neuron activity.
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Details
- Title
- Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity
- Creators
- Chen Yang - Air Force Medical UniversityYuzheng Hu - Zhejiang UniversityAleksandr D Talishinsky - National Institute on Drug AbuseChristian T Potter - National Institute on Drug AbuseColeman B Calva - National Institute on Drug AbuseLeslie A Ramsey - National Institute on Drug AbuseAndrew J Kesner - National Institute on Drug AbuseReuben F Don - National Institute on Drug AbuseSue Junn - National Institute on Drug AbuseAaron Tan - National Institute on Drug AbuseAnne F Pierce - National Institute on Drug AbuseCéline Nicolas - National Institute on Drug AbuseYosuke Arima - National Institute on Drug AbuseSeung-Chan Lee - National Institute on Drug AbuseConghui Su - Zhejiang UniversityJensine M Coudriet - National Institute on Drug AbuseCarlos A Mejia-Aponte - National Institute on Drug AbuseDong V Wang - National Institute on Drug AbuseHanbing Lu - National Institute on Drug AbuseYihong Yang - National Institute on Drug AbuseSatoshi Ikemoto - National Institute on Drug Abuse
- Publication Details
- Nature communications, v 13(1), pp 1386-1386
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000770096400018
- Scopus ID
- 2-s2.0-85125522927
- Other Identifier
- 991020099312704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences