Journal article
Medical and Household Characteristics Associated with Methicillin Resistant Staphylococcus aureus Nasal Carriage among Patients Admitted to a Rural Tertiary Care Hospital
PloS one, v 8(8), pp e73595-e73595
26 Aug 2013
PMID: 23991200
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Methicillin resistant Staphylococcus aureus (MRSA) poses a threat to patient safety and public health. Understanding how MRSA is acquired is important for prevention efforts. This study investigates risk factors for MRSA nasal carriage among patients at an eastern North Carolina hospital in 2011.
Methods: Using a case-control design, hospitalized patients ages 18 - 65 years were enrolled between July 25, 2011 and December 15, 2011 at Vidant Medical Center, a tertiary care hospital that screens all admitted patients for nasal MRSA carriage. Cases, defined as MRSA nasal carriers, were age and gender matched to controls, non-MRSA carriers. In-hospital interviews were conducted, and medical records were reviewed to obtain information on medical and household exposures. Multivariable conditional logistic regression was used to derive odds ratio (OR) estimates of association between MRSA carriage and medical and household exposures.
Results: In total, 117 cases and 119 controls were recruited to participate. Risk factors for MRSA carriage included having household members who took antibiotics or were hospitalized (OR: 3.27; 95% Confidence Interval (CI): 1.24-8.57) and prior hospitalization with a positive MRSA screen (OR: 3.21; 95% CI: 1.12-9.23). A lower proportion of cases than controls were previously hospitalized without a past positive MRSA screen (OR: 0.40; 95% CI: 0.19-0.87).
Conclusion: These findings suggest that household exposures are important determinants of MRSA nasal carriage in hospitalized patients screened at admission.
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Details
- Title
- Medical and Household Characteristics Associated with Methicillin Resistant Staphylococcus aureus Nasal Carriage among Patients Admitted to a Rural Tertiary Care Hospital
- Creators
- Leah Schinasi - University of North Carolina at Chapel HillSteve Wing - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USAPia D. M. MacDonald - University of North Carolina at Chapel HillDavid B. Richardson - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USAJill R. Stewart - University of North Carolina at Chapel HillKerri L. Augustino - Vidant Medical CenterDelores L. Nobles - Vidant Medical CenterKeith M. Ramsey - Vidant Medical Center
- Publication Details
- PloS one, v 8(8), pp e73595-e73595
- Publisher
- Public Library Science
- Number of pages
- 7
- Grant note
- H. Michael and Barbara Arrighi Endowed Scholarship Fund UL1RR025747 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) 5-52665 / NC Occupational Safety and Health Education Research Center
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000324228800107
- Scopus ID
- 2-s2.0-84883070371
- Other Identifier
- 991020100063804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Microbiology