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Medulloblastoma: toward biologically based management
Journal article   Peer reviewed

Medulloblastoma: toward biologically based management

Ayman Samkari, Jason C White and Roger J Packer
Seminars in pediatric neurology, v 22(1), pp 6-13
Mar 2015
DOI: https://doi.org/10.1016/j.spen.2014.12.010
PMID: 25976255
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Brain Neoplasms - diagnosis Brain Neoplasms - therapy Disease Management Humans Medulloblastoma - diagnosis Medulloblastoma - therapy Molecular Biology
Medulloblastoma is the most common malignant brain tumor in children and, as such, has been the focus of tremendous efforts to genomically characterize it. What was once thought to be a single disease has been divided into multiple, molecularly unique subgroups through gene expression profiling. Each subgroup is not only unique in its origin and pathogenesis but also in the prognosis and potential therapeutic options. Targeted therapy of malignancies has long been the goal of clinical oncology. The progress made in the classification of medulloblastoma should be used as a model for future studies. With the evolution of epigenetic and genomic sequencing, especially when used in tandem with high-throughput pharmacologic screening protocols, the potential for subgroup-specific targeting is closer than ever. This review focuses on the development of the molecular classification system and its potential use in developing prognostic models as well as for the advancement of targeted therapeutic interventions.

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11 Record Views
18 citations in Web of Science
19 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Pediatrics
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