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Journal article
Membrane-induced interactions between curvature-generating protein domains: the role of area perturbation
AIMS biophysics, v 4(1), pp 107-120
01 Jan 2017
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Abstract
Membrane deformation by asymmetric crescent-shaped proteins such as BAR-domains is calculated, using a mean field model that accounts for both bending and area stretch deformations. The penalties associated with membrane bending and area perturbation lead to moderately long-ranged (order 10 nm), non-monotonic, membrane-induced interactions between proteins that may prevent the formation of closely packed aggregates. As a result, BAR-domain proteins may favor the formation of an ordered array with a specific separation between domains whose spacing is set by the ratio between the bending and area stretch moduli.
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Details
- Title
- Membrane-induced interactions between curvature-generating protein domains: the role of area perturbation
- Creators
- Nily Dan - Drexel UniversityDepartment of Chemical and Biological Engineering, Drexel University, 3101 Chestnut St, Philadelphia PA 19104, USA
- Publication Details
- AIMS biophysics, v 4(1), pp 107-120
- Publisher
- Amer Inst Mathematical Sciences-Aims
- Number of pages
- 14
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000396672200007
- Scopus ID
- 2-s2.0-85018646829
- Other Identifier
- 991019312353904721
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- Web of Science research areas
- Biophysics