Journal article
Membrane protein structural biology: the high throughput challenge
Journal of structural biology, v 142(1)
2003
PMID: 12718926
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Membrane proteins represent roughly one-third of the proteins encoded in the genome, yet fewer than 1% of the proteins are of known structure. High-throughput crystallography offers the hope of correcting this imbalance. In order for large-scale membrane protein structural biology to realize its full promise, however, significant technical challenges must be overcome, the two most substantial being facile protein overexpression and reliable methods for crystal growth.
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Details
- Title
- Membrane protein structural biology: the high throughput challenge
- Creators
- Patrick J Loll - Department of Biochemistry, Drexel University College of Medicine, Mailstop 497, New College Building, 245 North 15th Street, Philadelphia, PA 19102-1101, USA
- Publication Details
- Journal of structural biology, v 142(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000182711400013
- Scopus ID
- 2-s2.0-0037391134
- Other Identifier
- 991014878002004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology