Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Memory T cells need CD28 costimulation to remember
Seminars in immunology, v 21(2), pp 69-77
Apr 2009
PMID: 19268606
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The activation and expansion of naïve T cells require costimulatory signals provided by CD28 and TNF family members. In contrast, for many years it was believed that memory T cells do not require CD28 costimulation for expansion during secondary responses. This was based on in vitro experiments that suggested the re-activation of memory T cells is somewhat independent of costimulation. Recent in vivo evidence, however, has challenged this and shown that both CD4+ and CD8+ memory T cells require CD28 costimulation for maximal expansion and pathogen clearance. This requirement has important implications for host immunity, vaccine development and immunotherapeutics.
Metrics
Details
- Title
- Memory T cells need CD28 costimulation to remember
- Creators
- Alina C Boesteanu - Drexel UniversityPeter D Katsikis - Drexel University
- Publication Details
- Seminars in immunology, v 21(2), pp 69-77
- Publisher
- Elsevier
- Grant note
- R01 AI066215 / NIAID NIH HHS R01 AI066215-04 / NIAID NIH HHS R01 AI66215 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000264686000004
- Scopus ID
- 2-s2.0-62049085580
- Other Identifier
- 991019339706404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology