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Meningococcal Conjugate Vaccines Policy Update: Booster Dose Recommendations
Journal article   Open access   Peer reviewed

Meningococcal Conjugate Vaccines Policy Update: Booster Dose Recommendations

Michael T. Brady, Henry H. Bernstein, Carrie L. Byington, Kathryn M. Edwards, Margaret C. Fisher, Mary P. Glode, Mary Anne Jackson, Harry L. Keyserling, David W. Kimberlin, Yvonne A. Maldonado, …
Pediatrics (Evanston), v 128(6), pp 1213-1218
01 Dec 2011
DOI: https://doi.org/10.1542/peds.2011-2380
PMID: 22123893
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1542/peds.2011-2380View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Life Sciences & Biomedicine Pediatrics Science & Technology
The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention and the American Academy of Pediatrics approved updated recommendations for the use of quadravalent (serogroups A, C, W-135, and Y) meningococcal conjugate vaccines (Menactra [Sanofi Pasteur, Swiftwater, PA] and Menveo [Novartis, Basel, Switzerland]) in adolescents and in people at persistent high-risk of meningococcal disease. The recommendations supplement previous Advisory Committee on Immunization Practices and American Academy of Pediatrics recommendations for meningococcal vaccinations. Data were reviewed pertaining to immunogenicity in high-risk groups, bactericidal antibody persistence after immunization, current epidemiology of meningococcal disease, meningococcal conjugate vaccine effectiveness, and cost-effectiveness of different strategies for vaccination of adolescents. This review prompted the following recommendations: (1) adolescents should be routinely immunized at 11 through 12 years of age and given a booster dose at 16 years of age; (2) adolescents who received their first dose at age 13 through 15 years should receive a booster at age 16 through 18 years or up to 5 years after their first dose; (3) adolescents who receive their first dose of meningococcal conjugate vaccine at or after 16 years of age do not need a booster dose; (4) a 2-dose primary series should be administered 2 months apart for those who are at increased risk of invasive meningococcal disease because of persistent complement component (eg, C5-C9, properdin, factor H, or factor D) deficiency (9 months through 54 years of age) or functional or anatomic asplenia (2-54 years of age) and for adolescents with HIV infection; and (5) a booster dose should be given 3 years after the primary series if the primary 2-dose series was given from 2 through 6 years of age and every 5 years for persons whose 2-dose primary series or booster dose was given at 7 years of age or older who are at risk of invasive meningococcal disease because of persistent component (eg, C5-C9, properdin, factor H, or factor D) deficiency or functional or anatomic asplenia. Pediatrics 2011;128:1213-1218

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