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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Menopausal hormone therapy and change in physical activity in the Women's Health Initiative hormone therapy clinical trials
Menopause (New York, N.Y.)
01 Aug 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVEThe menopausal transition results in a progressive decrease in circulating estrogen levels. Experimental evidence in rodents has indicated that estrogen depletion leads to a reduction of energy expenditure and physical activity. It is unclear whether treatment with estrogen therapy increases physical activity level in postmenopausal women. METHODSA total of 27,327 postmenopausal women aged 50-79 years enrolled in the Women's Health Initiative randomized double-blind trials of menopausal hormone therapy. Self-reported leisure-time physical activity at baseline, and years 1, 3, and 6 was quantified as metabolic equivalents (MET)-h/wk. In each trial, comparison between intervention and placebo groups of changes in physical activity levels from baseline to follow-up assessment was examined using linear regression models. RESULTSIn the CEE-alone trial, the increase in MET-h/wk was greater in the placebo group compared with the intervention group at years 3 (P = 0.002) and 6 (P < 0.001). Similar results were observed when analyses were restricted to women who maintained an adherence rate ≥80% during the trial or who were physically active at baseline. In the CEE + MPA trial, the primary analyses did not show significant differences between groups, but the increase of MET-h/wk was greater in the placebo group compared with the intervention group at year 3 (P = 0.004) among women with an adherence rate ≥80%. CONCLUSIONSThe results from this clinical trial do not support the hypothesis that estrogen treatment increases physical activity among postmenopausal women.
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Details
- Title
- Menopausal hormone therapy and change in physical activity in the Women's Health Initiative hormone therapy clinical trials
- Creators
- Rita PeilaXiaonan XueMichael J LaMonteAladdin H ShadyabJean Wactawski-WendeSu Yon JungKaren C JohnsonMace CodayPhyllis RicheyCharles P MoutonNazums SaquibRowan T ChlebowskiKathy PanYvonne L MichaelMeryl S LeBoffJoAnn E MansonThomas E Rohan
- Publication Details
- Menopause (New York, N.Y.)
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001059158100005
- Scopus ID
- 2-s2.0-85168800823
- Other Identifier
- 991020825193204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology