Journal article
Menstrual and reproductive factors in relation to risk of endometrial cancer in Chinese women
Cancer causes & control, v 17(7), pp 949-955
01 Sep 2006
PMID: 16841262
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Menstrual, reproductive and contraceptive factors have been associated with risk of endometrial cancer in populations where the incidence of this tumor is high. To investigate associations between these factors in a low-risk population with a low prevalence of hormone replacement therapy, we conducted a cohort study among 267,400 women employed in the textile industry in Shanghai, China. Menstrual, reproductive and other factors were ascertained at baseline in 1989-1991, and women were followed for incident endometrial cancer through 31 December 1998 (n = 206). Cox proportional hazards modeling was used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Risk of endometrial cancer decreased with increasing age at menarche (p-trend = 0.004). Among menopausal women, risk increased with age at menopause and increasing years of menstruation. Compared to women with one live birth, risk was increased in relation to nulliparity (Hazard ratio = 3.95, 95% CI 1.43-10.86). Risk was decreased with increasing age at first live birth (p-trend = 0.03). There was a decreased risk associated with ever use of an intrauterine device (HR = 0.56, 95% CI 0.35-0.88) and use of oral contraceptives for > or =2 years (HR = 0.50, 95% CI 0.23-1.07). This prospective study confirms findings from previous case-control studies relating menstrual, reproductive, and contraceptive factors and endometrial carcinoma.
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Details
- Title
- Menstrual and reproductive factors in relation to risk of endometrial cancer in Chinese women
- Creators
- Karen J Wernli - Fred Hutchinson Cancer Research CenterRoberta M Ray - Fred Hutchinson Cancer Research CenterDao Li Gao - Zhongshan HospitalAnneclaire J De Roos - University of WashingtonHarvey Checkoway - University of WashingtonDavid B Thomas - Fred Hutchinson Cancer Research Center
- Publication Details
- Cancer causes & control, v 17(7), pp 949-955
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000239040100009
- Scopus ID
- 2-s2.0-33746054926
- Other Identifier
- 991020100052804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health