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Mesenteric unicentric Castleman’s disease misdiagnosed as gastrointestinal neuroendocrine tumour
Journal article   Peer reviewed

Mesenteric unicentric Castleman’s disease misdiagnosed as gastrointestinal neuroendocrine tumour

Gordon Hua, David Barker, Xuemei Wu, Yazan Samhouri and Casey J Allen
BMJ case reports, v 19(2), e265307
19 Feb 2026
DOI: https://doi.org/10.1136/bcr-2025-265307
PMID: 41713893

Abstract

Gastrointestinal Surgery Immunology Surgery Surgical Oncology
Castleman’s disease is a rare lymphoproliferative disorder with a variable presentation ranging from no clinical symptoms to fever and fatigue. We report a case of a male in his 30s who presented to the emergency department with non-specific symptoms, including fever, cough, diarrhoea, abdominal pain and findings of bloody mucus in his stool. Preoperative imaging using CT showed a hypervascular mass in the abdomen measuring 3.9 cm. Positron emission tomography with Gallium-68 DOTA-Tyr3-octreotate (DOTATATE) showed moderate radiotracer uptake, raising suspicion for a neuroendocrine tumour. Preoperative endoscopic ultrasound biopsy results showed a benign reactive lymph node. The patient’s case was discussed at a multidisciplinary tumour board, where diagnostic/therapeutic resection was advised. Following resection of the mass, it was found to be an enlarged lymph node with histopathological features consistent with hyaline vascular Castleman’s disease. The patient did not experience any complications, postoperative imaging was unremarkable, and he is being monitored closely for recurrence.

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Collaboration types
Domestic collaboration
Web of Science research areas
Oncology
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