Journal article
Mesenteric vein thrombosis in a patient heterozygous for factor V Leiden and G20210A prothrombin genotypes
World journal of gastroenterology : WJG, v 19(43), pp 7813-7815
21 Nov 2013
PMID: 24282370
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mesenteric venous thrombosis (MVT) is a rare but life threatening form of bowel ischemia. It is implicated in 6%-9% of all cases of acute mesenteric ischemia. The proportion of patients with primary (or idiopathic) MVT varies from 0% to 49%, with a decrease in frequency secondary to more recent availability of newer investigations for hypercoagulability. The presence of factor V Leiden (FVL) and prothrombin G20210A mutations (PGM) have been well documented in these cases. However, there have been scarce case reports describing MVT in heterozygotes of both these mutations occurring simultaneously and its implications on long term management. Our case describes acute MVT in a previously asymptomatic young patient with no prior history of venous thromboembolism. The patient was found to be heterozygous for FVL and PGM and treated with lifelong anticoagulation with warfarin (goal international normalized ratio: 2-3) and avoidance of hormonal contraceptives. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
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Details
- Title
- Mesenteric vein thrombosis in a patient heterozygous for factor V Leiden and G20210A prothrombin genotypes
- Creators
- Paras Karmacharya - Reading HospitalMadan Raj Aryal - Reading Hlth Syst, Dept Internal Med, W Reading, PA 19611 USAAnthony Donato - Reading Hospital
- Publication Details
- World journal of gastroenterology : WJG, v 19(43), pp 7813-7815
- Publisher
- Baishideng Publishing Group Inc
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000327519000037
- Scopus ID
- 2-s2.0-84888115490
- Other Identifier
- 991022161836804721
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- Web of Science research areas
- Gastroenterology & Hepatology