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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation
Nature neuroscience, v 18(5), pp 728-735
May 2015
PMID: 25867120
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sharp wave-associated field oscillations (∼200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal ripple activity and memory consolidation. We performed in vivo simultaneous recording in the MnR and hippocampus of mice and found that, when a group of MnR neurons was active, ripples were absent. Consistently, optogenetic stimulation of MnR neurons suppressed ripple activity and inhibition of these neurons increased ripple activity. Notably, using a fear conditioning procedure, we found that photostimulation of MnR neurons interfered with memory consolidation. Our results demonstrate a critical role of the MnR in regulating ripples and memory consolidation.
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Details
- Title
- Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation
- Creators
- Dong V Wang - National Institute on Drug AbuseHau-Jie Yau - National Institute on Drug AbuseCarl J Broker - National Institute on Drug AbuseJen-Hui Tsou - National Institute on Drug AbuseAntonello Bonci - National Institute on Drug AbuseSatoshi Ikemoto - National Institute on Drug Abuse
- Publication Details
- Nature neuroscience, v 18(5), pp 728-735
- Publisher
- Springer Nature
- Grant note
- ZIA DA000575-04 / Intramural NIH HHS ZIA DA000550-06 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000353636900020
- Scopus ID
- 2-s2.0-84928698501
- Other Identifier
- 991020099916304721
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- Web of Science research areas
- Neurosciences