Journal article
Mesoporous carbide-derived carbon for cytokine removal from blood plasma
Biomaterials, v 31(18), pp 4789-4794
Jun 2010
PMID: 20303167
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Porous carbons can be used for purification of bio-fluids due to their excellent biocompatibility with blood. Since the ability to adsorb a range of inflammatory cytokines within the shortest possible time is crucial to stop the progression of sepsis, the improvement of the adsorption rate is a key factor to achieving efficient removal of cytokines. Here, we demonstrate the effect of synthesis temperatures (from 600°C to 1200°C), carbon particle sizes (from below 35μm to 300μm), and annealing conditions (Ar, NH3, H2, Cl2, and vacuum annealing) that determine the surface chemistry, on the ability of carbide-derived carbons (CDCs) to remove cytokines TNF-α, IL-6, and IL-1β from blood plasma. Optimization of CDC processing and structure leads to up to two orders of magnitude increase in the adsorption rate. Mesoporous CDCs that were produced at 800°C from Ti2AlC with the precursor particle size of <35μm and annealed in NH3, displayed complete removal of large molecules of TNF-α in less than an hour, with >85% and >95% TNF-α removal in 5 and 30min, respectively. This is a very significant improvement compared to the previously published results for CDC (90% TNF-α removal after 1h) and activated carbons. Smaller interleukin IL-6 and IL-1β molecules can be completely removed within 5min. These differences in adsorption rates show that carbons with controlled porosity can also be used for separation of protein molecules.
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Details
- Title
- Mesoporous carbide-derived carbon for cytokine removal from blood plasma
- Creators
- Saujanya Yachamaneni - Department of Materials Science and Engineering and A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA 19104, USAGleb Yushin - School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0245, USASun-Hwa Yeon - Department of Materials Science and Engineering and A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA 19104, USAYury Gogotsi - Department of Materials Science and Engineering and A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA 19104, USACarol Howell - The Centre for Biomedical and Health Science Research, University of Brighton, Brighton BN2 4GJ, UKSusan Sandeman - The Centre for Biomedical and Health Science Research, University of Brighton, Brighton BN2 4GJ, UKGary Phillips - The Centre for Biomedical and Health Science Research, University of Brighton, Brighton BN2 4GJ, UKSergey Mikhalovsky - The Centre for Biomedical and Health Science Research, University of Brighton, Brighton BN2 4GJ, UK
- Publication Details
- Biomaterials, v 31(18), pp 4789-4794
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000277783100001
- Scopus ID
- 2-s2.0-77951954347
- Other Identifier
- 991014878003304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials