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SubmittedOpen Access (License Unspecified), Open Access
Journal article
Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines
Biomaterials, v 27(34), pp 5755-5762
01 Dec 2006
PMID: 16914195
Abstract
Porous carbons can be used for the purification of various bio-fluids, including the cleansing blood of inflammatory mediators in conditions such as sepsis or auto-immune diseases. Here we show that the control of pore size in carbons is a key factor to achieving efficient removal of cytokines. In particular, the surface area accessible by the protein governs the rate and effectiveness of the adsorption process. We demonstrate that novel mesoporous carbon materials synthesized from ternary MAX-phase carbides can be optimized for efficient adsorption of large inflammatory proteins. The synthesized carbons, having tunable pore size with a large volume of slit-shaped mesopores, outperformed all other materials or methods in terms of efficiency of TNF-
α removal and the results are comparable only with highly specific antibody–antigen interactions.
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Details
- Title
- Mesoporous carbide-derived carbon with porosity tuned for efficient adsorption of cytokines
- Creators
- Gleb Yushin - Department of Materials Science and Engineering and A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA 19104, USAElizabeth N. Hoffman - Department of Materials Science and Engineering and A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA 19104, USAMichel W. Barsoum - Drexel University, Materials Science and EngineeringYury Gogotsi - Drexel University, Materials Science and EngineeringCarol A. Howell - School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UKSusan R. Sandeman - University of BrightonGary J. Phillips - School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UKAndrew W. Lloyd - School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UKSergey V. Mikhalovsky - University of Brighton
- Publication Details
- Biomaterials, v 27(34), pp 5755-5762
- Publisher
- Elsevier
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000241272300001
- Scopus ID
- 2-s2.0-33747853561
- Other Identifier
- 991014632731204721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials