Journal article
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Nature communications, Vol.10(1)
23 Apr 2019
Abstract
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.
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- Title
- Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
- Creators
- Leanne K KupersClaire MonnereauGemma C SharpPaul YousefiLucas A SalasAkram GhantousChristian M PageSarah E ReeseAllen J WilcoxDarina CzamaraAnne P StarlingAlexei NovoloacaSamantha LentRitu RoyCathrine HoyoCarrie BretonCatherine AllardAllan C JustKelly M BakulskiJohn W HollowayTodd M EversonCheng-Jian XuRae-Chi HuangDiana A van der PlaatMatthias WielscherSimon Kebede MeridVilhelmina UllemarFaisal RezwanJari LahtiJenny van DongenSabine A. S LangieTom G RichardsonMaria C MagnusEllen A NohrZongli XuLiesbeth DuijtsShanshan ZhaoWeiming ZhangMichelle PlusquinDawn L DeMeoOlivia SolomonJoosje H HeimovaaraDereje D JimaLu GaoMariona BustamantePatrice PerronRobert O WrightIrva Hertz-PicciottoHongmei ZhangMargaret R KaragasUlrike GehringCarmen J MarsitLawrence J BeilinJudith M VonkMarjo-Riitta JarvelinAnna BergstromAnne K OrtqvistSusan EwartPia M VillaSophie E MooreGonneke WillemsenArnout R. L StandaertSiri E HabergThorkild I. A SorensenJack A TaylorKatri RaikkonenIvana YangKaterina KechrisTim S NawrotMatt J SilverYun Yun GongLorenzo RichiardiManolis KogevinasAugusto A LitonjuaBrenda EskenaziKaren HuenHamdi MbarekRachel L MaguireTerence DwyerMartine VrijheidLuigi BouchardAnea A BaccarelliLisa A CroenWilfried KarmausDenise AndersonMaaike de VriesSylvain SebertJuha KereRobert KarlssonSyed Hasan ArshadEsa HamalainenMichael N RoutledgeDorret BoomsmaAnew P FeinbergCraig J NewschafferEva GovartsMatthieu MoisseM. Daniele FallinErik MelenAnew M PrenticeEero KajantieCatarina AlmqvistEmily OkenDana DabeleaH. Marike BoezenPhillip E MeltonRosalind J WrightGerard H KoppelmanLetizia TrevisiMarie-France HivertJordi SunyerMonica C Munthe-KaasSusan K MurphyEva CorpeleijnJoseph WiemelsNina HollandZdenko HercegElisabeth B BinderGeorge Davey SmithVincent W. V JaddoeRolv T LieWenche NystadStephanie J LondonDebbie A LawlorCaroline L ReltonHarold SniederJanine F Felix
- Publication Details
- Nature communications, Vol.10(1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Identifiers
- 991019231659604721