Journal article
Meta-analysis of material properties influencing nanoparticle plasma pharmacokinetics
International journal of pharmaceutics, v 639, 122951
25 May 2023
PMID: 37059242
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Thorough characterization of the plasma pharmacokinetics (PK) is a critical step in clinical development of novel therapeutics and is routinely performed for small molecules and biologics. However, there is a paucity of even basic characterization of PK for nanoparticle-based drug delivery systems. This has led to untested generalizations about how nanoparticle properties govern PK. Here, we present a meta-analysis of 100 nanoparticle formulations following IV administration in mice to identify any correlations between four PK parameters derived by non-compartmental analysis (NCA) and four cardinal properties of nanoparticles: PEGylation, zeta potential, size, and material. There was a statistically significant difference between the PK of particles stratified by nanoparticle properties. However, single linear regression between these properties and PK parameters showed poor predictability (r2 < 0.10 for all analyses), while multivariate regressions showed improved predictability (r2 > 0.38, except for t1/2). This suggests that no single nanoparticle property alone is even moderately predictive of PK, while the combination of multiple nanoparticle features does provide moderate predictive power. Improved reporting of nanoparticle properties will enable more accurate comparison between nanoformulations and will enhance our ability to predict in vivo behavior and design optimal nanoparticles.
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Details
- Title
- Meta-analysis of material properties influencing nanoparticle plasma pharmacokinetics
- Creators
- Briana Macedo - Princeton UniversityManthan Patel - Drexel UniversityMichael H. Zaleski - University of PennsylvaniaParth Mody - University of PennsylvaniaXiaonan Ma - University of PennsylvaniaPatrick Mei - University of PennsylvaniaJacob W. Myerson - University of PennsylvaniaJacob S. Brenner - University of PennsylvaniaPatrick M. Glassman - Temple University
- Publication Details
- International journal of pharmaceutics, v 639, 122951
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000984511600001
- Scopus ID
- 2-s2.0-85152545277
- Other Identifier
- 991021861171404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy