Journal article
Meta-analysis: vitamin D and non-alcoholic fatty liver disease
Alimentary pharmacology & therapeutics, v 38(3), pp 246-254
Aug 2013
PMID: 23786213
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition. Emerging evidence suggests that vitamin D may play a role in the pathogenesis of NAFLD.
Aim
To review systematically the association between vitamin D levels, measured as serum 25-hydroxy vitamin D [25(OH) D], and NAFLD.
Methods
We used PubMed and EMBASE databases to identify all studies that assessed the association between vitamin D and NAFLD up until 22 April 2013, without language restrictions. We included studies that compared vitamin D levels between NAFLD cases and controls and also those that compared the odds of vitamin D deficiency by NAFLD status. Pooled standardised differences and odds ratios were calculated using an inverse variance method.
Results
Seventeen cross-sectional and case-control studies have evaluated the association between vitamin D and NAFLD. NAFLD was diagnosed using biopsy (4 studies), ultrasound or CT (10 studies) and liver enzymes (3 studies). Nine studies provided data for a quantitative meta-analysis. Compared to controls, NAFLD patients had 0.36 ng/mL (95% CI: 0.32, 0.40 ng/mL) lower levels of 25(OH) D and were 1.26 times more likely to be vitamin D deficient (OR 1.26, 95% CI: 1.17, 1.35).
Conclusions
NAFLD patients have decreased serum 25(OH) D concentrations, suggesting that vitamin D may play a role in the development of NAFLD. The directionality of this association cannot be determined from cross-sectional studies. Demonstration of a causal role of hypovitaminosis D in NAFLD development in future studies could have important therapeutic implications.
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Details
- Title
- Meta-analysis: vitamin D and non-alcoholic fatty liver disease
- Creators
- M. Eliades - MedStar Washington Hospital CenterE. Spyrou - MedStar Washington Hospital CenterN. Agrawal - MedStar Washington Hospital CenterM. Lazo - Johns Hopkins MedicineF. L. Brancati - Johns Hopkins MedicineJ. J. Potter - Johns Hopkins UniversityA. A. Koteish - Johns Hopkins UniversityJ. M. Clark - Johns Hopkins UniversityE. Guallar - Johns Hopkins UniversityR. Hernaez - Johns Hopkins University
- Publication Details
- Alimentary pharmacology & therapeutics, v 38(3), pp 246-254
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- P30DK079637 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Community Health and Prevention
- Web of Science ID
- WOS:000321207100003
- Scopus ID
- 2-s2.0-84879160867
- Other Identifier
- 991022171265104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology
- Pharmacology & Pharmacy