Journal article
Metabolic Syndrome Biomarkers Predict Lung Function Impairment: A Nested Case-Control Study
American journal of respiratory and critical care medicine, Vol.185(4), pp.392-399
15 Feb 2012
PMCID: PMC3297095
PMID: 22095549
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rationale
: Cross-sectional studies demonstrate an association between metabolic syndrome and impaired lung function.
Objectives
: To define if metabolic syndrome biomarkers are risk factors for loss of lung function after irritant exposure.
Methods
: A nested case-control study of Fire Department of New York personnel with normal pre–September 11th FEV
1
and who presented for subspecialty pulmonary evaluation before March 10, 2008. We correlated metabolic syndrome biomarkers obtained within 6 months of World Trade Center dust exposure with subsequent FEV
1
. FEV
1
at subspecialty pulmonary evaluation within 6.5 years defined disease status; cases had FEV
1
less than lower limit of normal, whereas control subjects had FEV
1
greater than or equal to lower limit of normal.
Measurements and Main Results
: Clinical data and serum sampled at the first monitoring examination within 6 months of September 11, 2001, assessed body mass index, heart rate, serum glucose, triglycerides and high-density lipoprotein (HDL), leptin, pancreatic polypeptide, and amylin. Cases and control subjects had significant differences in HDL less than 40 mg/dl with triglycerides greater than or equal to 150 mg/dl, heart rate greater than or equal to 66 bpm, and leptin greater than or equal to 10,300 pg/ml. Each increased the odds of abnormal FEV
1
at pulmonary evaluation by more than twofold, whereas amylin greater than or equal to 116 pg/ml decreased the odds by 84%, in a multibiomarker model adjusting for age, race, body mass index, and World Trade Center arrival time. This model had a sensitivity of 41%, a specificity of 86%, and a receiver operating characteristic area under the curve of 0.77.
Conclusions
: Abnormal triglycerides and HDL and elevated heart rate and leptin are independent risk factors of greater susceptibility to lung function impairment after September 11, 2001, whereas elevated amylin is protective. Metabolic biomarkers are predictors of lung disease, and may be useful for assessing risk of impaired lung function in response to particulate inhalation.
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Details
- Title
- Metabolic Syndrome Biomarkers Predict Lung Function Impairment
- Creators
- Bushra Naveed - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New YorkMichael D Weiden - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New YorkSophia Kwon - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New YorkEdward J Gracely - Drexel University College of Medicine and Drexel University School of Public Health, Philadelphia, PennsylvaniaAshley L Comfort - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New YorkNatalia Ferrier - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New YorkKusali J Kasturiarachchi - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New YorkHillel W Cohen - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York; andThomas K Aldrich - Division of Pulmonary Medicine, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New YorkWilliam N Rom - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New YorkKerry Kelly - Bureau of Health Services and Office of Medical Affairs, Fire Department of New York City, Brooklyn, New YorkDavid J Prezant - Bureau of Health Services and Office of Medical Affairs, Fire Department of New York City, Brooklyn, New YorkAnna Nolan - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, New York
- Publication Details
- American journal of respiratory and critical care medicine, Vol.185(4), pp.392-399
- Publisher
- American Thoracic Society
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Identifiers
- 991014877836604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine
- Respiratory System