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Metabolic and bariatric surgery for obesity in Prader Willi syndrome: systematic review and meta-analysis
Journal article   Open access   Peer reviewed

Metabolic and bariatric surgery for obesity in Prader Willi syndrome: systematic review and meta-analysis

Gunnar Wolfe, Vesta Salehi, Allen Browne, Renee Riddle, Erin Hall, John Fam, David Tichansky and Stephan Myers
Surgery for obesity and related diseases, v 19(8), pp 907-915
01 Aug 2023
DOI: https://doi.org/10.1016/j.soard.2023.01.017
PMID: 36872159
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1016/j.soard.2023.01.017View
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Abstract

Adolescents Children Metabolic and bariatric surgery Prader-Willi syndrome Weight loss
Obesity is the leading cause of morbidity and mortality in patients with Prader-Willi Syndrome (PWS). Our objective was to compare changes in body mass index (BMI) after metabolic and bariatric surgery (MBS) for the treatment of obesity (BMI ≥35 kg/m2) in PWS. A systematic review of MBS in PWS was performed using PubMed, Embase, and Cochrane Central, identifying 254 citations. Sixty-seven patients from 22 articles met criteria for inclusion in the meta-analysis. Patients were organized into 3 groups: laparoscopic sleeve gastrectomy (LSG), gastric bypass (GB), and biliopancreatic diversion (BPD). No mortality within 1 year was reported in any of the 3 groups after a primary MBS operation. All groups experienced a significant decrease in BMI at 1 year with a mean reduction in BMI of 14.7 kg/m2 (P < .001). The LSG groups (n = 26) showed significant change from baseline in years 1, 2, and 3 (P value at year 3 = .002) but did not show significance in years 5, 7, and 10. The GB group (n = 10) showed a significant reduction in BMI of 12.1 kg/m2 in the first 2 years (P = .001). The BPD group (n = 28) had a significant reduction in BMI through 7 years with an average reduction of 10.7 kg/m2 (P = .02) at year 7. Individuals with PWS who underwent MBS had significant BMI reduction sustained in the LSG, GB, and BPD groups for 3, 2, and 7 years, respectively. No deaths within 1 year of these primary MBS operations were reported in this study or any other publication.

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9 citations in Web of Science
8 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Surgery
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