Journal article
Metabolism of cyclooxygenase and lipoxygenase products by 15-prostaglandin dehydrogenase from human HL-60 leukemia cells
Agents and actions, v 21(3-4), pp 397-399
01 Aug 1987
PMID: 3120517
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A number of prostaglandins and mono-hydroxylated fatty acids were investigated as substrates for NAD-dependent 15-prostaglandin dehydrogenase (15-PGDH) obtained from human HL-60 cells. Lipoxygenase and cyclooxygenase-derived substrates possessing an w-6 hydroxyl moiety (15-HETE, 13-HODD and HHT) were metabolized to corresponding keto derivatives at a rate comparable to that for prostaglandins E2 and F2 alpha. 12-HETE was a poor substrate and 5-HETE was not metabolized. The w-6 hydroxy fatty acids inhibited the metabolism of PGE2 and therefore they may play a role in modulating bioactive prostaglandin levels.
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Details
- Title
- Metabolism of cyclooxygenase and lipoxygenase products by 15-prostaglandin dehydrogenase from human HL-60 leukemia cells
- Creators
- A P Agins - Brown UniversityR E ZipkinI M Taffer
- Publication Details
- Agents and actions, v 21(3-4), pp 397-399
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences
- Web of Science ID
- WOS:A1987K053100054
- Scopus ID
- 2-s2.0-0023554556
- Other Identifier
- 991021229893704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Multidisciplinary
- Pharmacology & Pharmacy