Journal article
Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota
Environmental engineering science, v 32(7), pp 602-612
01 Jul 2015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nanoparticles (NPs) are becoming prevalent in consumer goods, including foods and cosmetics. Understanding the interactions between NPs and bacteria in an engineered model colon can indicate potential impacts of NP exposure on the gut, and therefore overall human health. Human microbiome health has important implications to overall individual health. This work aims at quantifying the phenotypic response to NP ingestion of a model microbial community within a model colon. Three NPs at environmentally relevant concentrations (0.01g/L ZnO, 0.01g/L CeO2, and 3mg/L TiO2) were individually introduced into a model colon to identify the subsequent impact on the gut microbial community. Results indicate that NPs cause the microbial community's phenotype to partition into three distinct phases: initial conditions, a transition period, and a homeostatic phase, with the NP-exposed community displaying significant differences (p<0.05) from the unexposed community in multiple phenotypic traits. Notably, phenotypes, including short-chain fatty acid (SCFA) production, hydrophobicity, sugar content of the extracellular polymeric substance, and electrophoretic mobility, which indicate changes in the community's stability, were affected by the NPs. TiO2 NPs led to extended phenotypic transformations for hydrophobicity when compared with the other NPs, likely due to its lack of dissociation and greater stability. Overall, the NPs caused nonlethal, significant changes to the microbial community's phenotype, which may be related to overall health effects.
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Details
- Title
- Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota
- Creators
- Alicia A. Taylor - Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USAIan M. Marcus - Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USARisa L. Guysi - Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USASharon L. Walker - Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA
- Publication Details
- Environmental engineering science, v 32(7), pp 602-612
- Publisher
- Mary Ann Liebert, Inc
- Number of pages
- 11
- Grant note
- DBI 0830117 / Environmental Protection Agency National Science Foundation; National Science Foundation (NSF) UC-CEIN (University of California Center for Environmental Implications of Nanotechnology) T32 ES018827 / National Research Service Award Institutional Training Grant
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Engineering
- Web of Science ID
- WOS:000363873200006
- Scopus ID
- 2-s2.0-84936937609
- Other Identifier
- 991021229892904721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Environmental
- Environmental Sciences