Journal article
Metal ion-assisted self-assembly of complexes for controlled and sustained release of minocycline for biomedical applications
Biofabrication, v 7(1), pp 015006-015006
20 Jan 2015
PMID: 25599696
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study reports the development of novel drug delivery complexes self-assembled by divalent metal ion-assisted coacervation for controlled and sustained release of a hydrophilic small drug molecule minocycline hydrochloride (MH). MH is a multifaceted agent that has demonstrated therapeutic effects in infection, inflammation, tumor, as well as cardiovascular, renal, and neurological disorders due to its anti-microbial, anti-inflammatory, and cytoprotective properties. However, the inability to translate the high doses used in experimental animals to tolerable doses in human patients limits its clinical application. Localized delivery can potentially expose the diseased tissue to high concentrations of MH that systemic delivery cannot achieve, while minimizing the side effects from systemic exposure. The strong metal ion binding-assisted interaction enabled high drug entrapment and loading efficiency, and stable long term release for more than 71 d. Released MH demonstrated potent anti-biofilm, anti-inflammatory, and neuroprotective activities. Furthermore, MH release from the complexes is pH-sensitive as the chelation between minocycline and metal ions decreases with pH, allowing 'smart' drug release in response to the severity of pathology-induced tissue acidosis. This novel metal ion binding-mediated drug delivery mechanism can potentially be applied to other drugs that have high binding affinity for metal ions and may lead to the development of new delivery systems for a variety of drugs.
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Details
- Title
- Metal ion-assisted self-assembly of complexes for controlled and sustained release of minocycline for biomedical applications
- Creators
- Zhiling Zhang - Drexel University School of Biomedical Engineering, Science and Health Systems, 3141 Chestnut Street, Philadelphia, PA 19104, USAZhicheng Wang - Drexel University School of Biomedical Engineering, Science and Health Systems, 3141 Chestnut Street, Philadelphia, PA 19104, USAJia Nong - Drexel University School of Biomedical Engineering, Science and Health Systems, 3141 Chestnut Street, Philadelphia, PA 19104, USACamilla A Nix - Drexel University School of Biomedical Engineering, Science and Health Systems, 3141 Chestnut Street, Philadelphia, PA 19104, USAHai-Feng Ji - Drexel University Department of Chemistry, 3141 Chestnut Street, Philadelphia, PA 19104, USAYinghui Zhong - Drexel University School of Biomedical Engineering, Science and Health Systems, 3141 Chestnut Street, Philadelphia, PA 19104, USA
- Publication Details
- Biofabrication, v 7(1), pp 015006-015006
- Publisher
- IOP Publishing
- Number of pages
- 13
- Grant note
- R21NS084379 / National Institute of Neurological Disorders and Stroke (10.13039 100000065)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000353341000007
- Scopus ID
- 2-s2.0-84924303306
- Other Identifier
- 991014878020504721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials