Journal article
Metalated Nitrile and Enolate Chlorinations
Organic letters, v 12(12), pp 2810-2813
18 Jun 2010
PMID: 20481460
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Metalated nitriles and enolates rapidly and efficiently abstract chlorine from 2-chloro-2-fluoro-2-phenylacetonitrile to afford a diverse range of chloronitriles and chloroesters. The method provides the first general anionic chlorination of alkylnitriles, tolerates numerous functional groups, and addresses the challenge of synthesizing alpha-chloronitriles under mild conditions.
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Details
- Title
- Metalated Nitrile and Enolate Chlorinations
- Creators
- Bhaskar Reddy Pitta - Duquesne UniversityFraser F. Fleming - Duquesne University
- Publication Details
- Organic letters, v 12(12), pp 2810-2813
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 4
- Grant note
- 0808996 CHE; 0421252 HRMS; 0614785 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000278616800034
- Scopus ID
- 2-s2.0-77953584940
- Other Identifier
- 991020898495404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Organic