Journal article
Metastable gels: A novel application of Ogston theory to sickle hemoglobin polymers
Biophysical chemistry, v 154(2-3)
01 Mar 2011
PMID: 21334802
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sickle hemoglobin differs from normal adult hemoglobin by its ability to polymerize, which occurs at relatively high concentrations since the solubility for polymerization is typically above 160 mg/ml. We have recently found that the gel formed by polymers is metastable if the gel is not centrifuged or aged for long times in that polymerization ceases before the monomer concentration has decreased from its original value to the solubility. We have proposed that this effect is due to the obstruction of ends by other polymers in the crowded gel. Here we use Ogston's theory describing spaces amid arrays of random rods to provide a framework for describing the failure of the polymers to propagate. We find good agreement between fiber diameter and minimum void spaces. This novel application of a well-established theoretical framework for crowding may apply to other dense gels as well. (C) 2011 Elsevier B.V. All rights reserved.
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Details
- Title
- Metastable gels: A novel application of Ogston theory to sickle hemoglobin polymers
- Creators
- Weijun Weng - Drexel UniversityFrank A. Ferrone - Drexel University
- Publication Details
- Biophysical chemistry, v 154(2-3)
- Publisher
- Elsevier
- Number of pages
- 3
- Grant note
- R01HL057549 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P01 HL058512; R01 HL057549 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000289140200007
- Scopus ID
- 2-s2.0-79952585901
- Other Identifier
- 991019169710104721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Chemistry, Physical