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Metastatic Seeding Attacks Bone Marrow, Not Bone Rectifying Ongoing Misconceptions
Journal article

Metastatic Seeding Attacks Bone Marrow, Not Bone Rectifying Ongoing Misconceptions

William Y. Raynor, Abdullah Al-Zaghal, Mahdi Zirakchian Zadeh, Siavash Mehdizadeh Seraj and Abass Alavi
PET clinics, v 14(1), pp 135-144
01 Jan 2019
PMID: 30420215

Abstract

Life Sciences & Biomedicine Radiology, Nuclear Medicine & Medical Imaging Science & Technology
Conventional modalities, such as bone scintigraphy, are commonly used to assess osseous abnormalities in skeletal metastasis. Fluorine-18 (F-18)-sodium fluoride (NaF) PET similarly portrays osteoblastic activity but with improved spatial and contrast resolution and more accurate anatomic localization. However, these modalities rely on indirect evidence for tumor activity. PET imaging with F-18-fluorodeoxyglucose (FDG) and tumor-specific tracers may have an increased role by directly portraying the metabolic activity of cancer cells, which are often seeded in bone marrow and cause osseous disease after initial latency. This article describes the utility and limitations of these modalities in assessing skeletal metastases.

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Collaboration types
Domestic collaboration
Web of Science research areas
Radiology, Nuclear Medicine & Medical Imaging
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