Journal article
Metastatic Seeding Attacks Bone Marrow, Not Bone Rectifying Ongoing Misconceptions
PET clinics, v 14(1), pp 135-144
01 Jan 2019
PMID: 30420215
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Conventional modalities, such as bone scintigraphy, are commonly used to assess osseous abnormalities in skeletal metastasis. Fluorine-18 (F-18)-sodium fluoride (NaF) PET similarly portrays osteoblastic activity but with improved spatial and contrast resolution and more accurate anatomic localization. However, these modalities rely on indirect evidence for tumor activity. PET imaging with F-18-fluorodeoxyglucose (FDG) and tumor-specific tracers may have an increased role by directly portraying the metabolic activity of cancer cells, which are often seeded in bone marrow and cause osseous disease after initial latency. This article describes the utility and limitations of these modalities in assessing skeletal metastases.
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Details
- Title
- Metastatic Seeding Attacks Bone Marrow, Not Bone Rectifying Ongoing Misconceptions
- Creators
- William Y. Raynor - Drexel UniversityAbdullah Al-Zaghal - University of PennsylvaniaMahdi Zirakchian Zadeh - Children's Hospital of PhiladelphiaSiavash Mehdizadeh Seraj - University of PennsylvaniaAbass Alavi - University of Pennsylvania
- Publication Details
- PET clinics, v 14(1), pp 135-144
- Publisher
- Elsevier
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000449775000012
- Scopus ID
- 2-s2.0-85056214724
- Other Identifier
- 991019350674604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging