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Journal article
Methods for Evaluating the Combined Effects of Chemical and Nonchemical Exposures for Cumulative Environmental Health Risk Assessment
International journal of environmental research and public health, v 15(12), p2797
01 Dec 2018
PMCID: PMC6313653
PMID: 30544651
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cumulative risk assessment (CRA) has been proposed as a means of evaluating possible additive and synergistic effects of multiple chemical, physical and social stressors on human health, with the goal of informing policy and decision-making, and protecting public health. Routine application of CRA to environmental regulatory and policy decision making, however, has been limited due to a perceived lack of appropriate quantitative approaches for assessing combined effects of chemical and nonchemical exposures. Seven research projects, which represented a variety of disciplines, including population health science, laboratory science, social sciences, geography, statistics and mathematics, were funded by the US Environmental Protection Agency (EPA) to help address this knowledge gap. We synthesize key insights from these unique studies to determine the implications for CRA practice and priorities for further research. Our analyses of these seven projects demonstrate that the necessary analytical methods to support CRA are available but are ultimately context-dependent. These projects collectively provided advancements for CRA in the areas of community engagement, characterization of exposures to nonchemical stressors, and assessment of health effects associated with joint exposures to chemical and psychosocial stressors.
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Details
- Title
- Methods for Evaluating the Combined Effects of Chemical and Nonchemical Exposures for Cumulative Environmental Health Risk Assessment
- Creators
- Devon C. Payne-Sturges - University of Maryland, BaltimoreMadeleine K. Scammell - Boston UniversityJonathan I. Levy - Boston UniversityDeborah A. Cory-Slechta - University of RochesterElaine Symanski - The University of Texas Health Science Center at HoustonJessie L. Carr Shmool - University of PittsburghRobert Laumbach - Environmental and Occupational Health Sciences InstituteStephen Linder - Institute for Health Policy, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Pressler, Houston, TX 77030, USA. stephen.h.linder@uth.tmc.edu.Jane E. Clougherty - Drexel University
- Publication Details
- International journal of environmental research and public health, v 15(12), p2797
- Publisher
- Mdpi
- Number of pages
- 21
- Grant note
- R834576; R834577; R834578; R834579; R834580; R834581; R834582; P30 ES005022 / US Environmental Protection Agency STAR; United States Environmental Protection Agency P30ES005022 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000456527000188
- Scopus ID
- 2-s2.0-85058346635
- Other Identifier
- 991019168170404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health