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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets
Journal of Visualized Experiments, v 2019(154)
2019
PMID: 31904013
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neonatal brachial plexus palsy (NBPP) is a stretch injury that occurs during the birthing process in nerve complexes located in the neck and shoulder regions, collectively referred to as the brachial plexus (BP). Despite recent advances in obstetrical care, the problem of NBPP continues to be a global health burden with an incidence of 1.5 cases per 1,000 live births. More severe types of this injury can cause permanent paralysis of the arm from the shoulder down. Prevention and treatment of NBPP warrants an understanding of the biomechanical and physiological responses of newborn BP nerves when subjected to stretch. Current knowledge of the newborn BP is extrapolated from adult animal or cadaveric BP tissue instead of in vivo neonatal BP tissue. This study describes an in vivo mechanical testing device and procedure to conduct in vivo biomechanical testing in neonatal piglets. The device consists of a clamp, actuator, load cell, and camera system that apply and monitor in vivo strains and loads until failure. The camera system also allows monitoring of the failure location during rupture. Overall, the presented method allows for a detailed biomechanical characterization of neonatal BP when subjected to stretch.
Metrics
Details
- Title
- Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets
- Creators
- Anita Singh - Widener UniversityRachel Magee - Widener UniversitySriram Balasubramanian - Drexel University
- Publication Details
- Journal of Visualized Experiments, v 2019(154)
- Publisher
- MyJove Corporation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000505787900007
- Scopus ID
- 2-s2.0-85077480091
- Other Identifier
- 991019167527404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics