Journal article
Methylene blue does not neutralize heparin after cardiopulmonary bypass
Journal of cardiothoracic and vascular anesthesia, v 10(4), pp 474-476
1996
PMID: 8776640
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It was hypothesized that methylene blue could neutralize heparin in patients after cardiopulmonary bypass and become an alternative to protamine.
This was a prospective unblinded study with patients serving as their own controls.
A single, large university hospital. This study was conducted in patients scheduled for elective aortocoronary bypass grafting.
When heparin was to be neutralized, patients received methylene blue, 2 to 12 mg/kg, diluted in 50 mL and infused over 20 minutes. If a clot was not observed or the activated coagulation time (ACT) remained elevated, protamine, 250 mg, was administered and the ACT was repeated.
No patient demonstrated clot after methylene blue infusion. ACT did not return to preheparin values in any patient. All patients required protamine to establish hemostasis. Protamine restored the ACT to preheparin values in every patient. The one patient who received 12 mg/kg experienced severe pulmonary hypertension.
Methylene blue does not neutralize heparin after cardiopulmonary bypass.
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Details
- Title
- Methylene blue does not neutralize heparin after cardiopulmonary bypass
- Creators
- Samuel Metz - Hahnemann University HospitalJan C. Horrow - Hahnemann University HospitalInder P. Goel - Hahnemann University HospitalM.L.R. Kuretu - Hahnemann University HospitalCollette Bellwoar - Hahnemann University HospitalJay C Horrow - Anesthesiology and Perioperative Medicine
- Publication Details
- Journal of cardiothoracic and vascular anesthesia, v 10(4), pp 474-476
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:A1996UP20700007
- Scopus ID
- 2-s2.0-0029949778
- Other Identifier
- 991019168121004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Anesthesiology
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease
- Respiratory System