Logo image
Back
Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span
Journal article   Open access   Peer reviewed

Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span

Antonello Lorenzini, Adam B. Salmon, Chad Lerner, Claudio Torres, Yuji Ikeno, Susan Motch, Roger McCarter and Christian Sell
The journals of gerontology. Series A, Biological sciences and medical sciences, v 69(4), pp 410-419
20 Jul 2013
DOI: https://doi.org/10.1093/gerona/glt108
PMID: 23873963
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1093/gerona/glt108View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Gluconeogenesis IGF-1 Insulin Metabolism Obesity Original
Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that reducing levels of IGF-1 may also increase life span. However, the data are conflicting and complicated by the physiology of the mammalian neuroendocrine system. We have performed life-span analysis on mice homozygous for an insertion in the Igf1 gene. These mice produce reduced levels of IGF-1 and display a phenotype consistent with a significant decrease in IGF-1. Life-span analysis was carried out at three independent locations. Although the life-span data varied between sites, the maximum life span of the IGF-1-deficient mice was significantly increased and age-specific mortality rates were reduced in the IGF-1-deficient mice; however, mean life span did not differ except at one site, where mean life span was increased in female IGF-1-deficient animals. Early life mortality was noted in one cohort of IGF-1-deficient mice. The results are consistent with a significant role for IGF-1 in the modulation of life span but contrast with the published life-span data for the hypopituitary Ames and Snell dwarf mice and growth hormone receptor null mice, indicating that a reduction in IGF-1 alone is insufficient to increase both mean and maximal life span in mice.

Metrics

9 Record Views
37 citations in Web of Science
40 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Geriatrics & Gerontology
Gerontology
Logo image