Journal article
MicroRNA-148a-3p is a candidate mediator of increased bone marrow adiposity and bone loss following spinal cord injury
FRONTIERS IN ENDOCRINOLOGY, v 13, 910934
05 Aug 2022
PMID: 35992108
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal cord injury is often followed by osteoporosis characterized by rapid and severe bone loss. This leads to an increased risk of osteoporotic fracture in people with spinal cord injury, resulting in increased healthcare costs, morbidity, and mortality. Though it is common, the mechanisms underlying this osteoporosis are not completely understood and treatment options are limited. No biomarkers have been identified for predicting fracture risk. In this study, we sought to investigate microRNA mediated mechanisms relating to osteoporosis following spinal cord injury. We studied subjects with acute SCI (n=12), chronic SCI (n=18), and controls with no SCI (n=23). Plasma samples from all subjects underwent transcriptomic analysis to quantify microRNA expression, after which miR-148a-3p was selected for further study. We performed CT scans of the knee on all subjects with SCI and analyzed these scans to quantify bone marrow adipose tissue volume. MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI. Subjects with chronic SCI had greater levels of marrow adiposity in the distal femoral diaphysis compared to subjects with acute SCI. MiR-148a-3p levels were negatively associated with distal femoral diaphysis marrow adiposity. A multivariable model showed that miR-148a-3p and BMI explained 24% of variation in marrow adiposity. A literature search revealed that miR-148a-3p has multiple bone and fat metabolism related targets. Our findings suggest that miR-148a-3p is a mediator of osteoporosis following spinal cord injury and a potential future therapeutic target.
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Details
- Title
- MicroRNA-148a-3p is a candidate mediator of increased bone marrow adiposity and bone loss following spinal cord injury
- Publication Details
- FRONTIERS IN ENDOCRINOLOGY, v 13, 910934
- Publisher
- FRONTIERS MEDIA SA; LAUSANNE
- Grant note
- This study received support from the Department of Defense (Q81XWH-15-2-0078), National Institutes of Health (R01AR064793) and The National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR, 90SI5015-01-00). Additional support was provided by the Rehabilitation Research Experience for Medical Students (RREMS) through the Association of Academic Physiatrists, the Foundation for PM&R, and the Craig H. Neilsen Foundation.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000844866000001
- Scopus ID
- 2-s2.0-85136624862
- Other Identifier
- 991021860726604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism