Journal article
MicroRNAs and HIV-1: Complex Interactions
The Journal of biological chemistry, v 287(49), pp 40884-40890
30 Nov 2012
PMID: 23043098
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
RNAi plays important roles in many biological processes, including cellular defense against viral infection. Components of the RNAi machinery are widely conserved in plants and animals. In mammals, microRNAs (miRNAs) represent an abundant class of cell encoded small noncoding RNAs that participate in RNAi-mediated gene silencing. Here, findings that HIV-1 replication in cells can be regulated by miRNAs and that HIV-1 infection of cells can alter cellular miRNA expression are reviewed. Lessons learned from and questions outstanding about the complex interactions between HIV-1 and cellular miRNAs are discussed.
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Details
- Title
- MicroRNAs and HIV-1: Complex Interactions
- Creators
- Zachary Klase - National Institutes of HealthLaurent Houzet - National Institutes of HealthKuan-Teh Jeang - From the Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892
- Publication Details
- The Journal of biological chemistry, v 287(49), pp 40884-40890
- Publisher
- American Society for Biochemistry and Molecular Biology
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000311887600007
- Scopus ID
- 2-s2.0-84870378445
- Other Identifier
- 991021902507204721
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- Web of Science research areas
- Biochemistry & Molecular Biology