Journal article
MicroRNAs downregulated following immune activation of rat testis
American journal of reproductive immunology (1989), v 77(6), e12673
01 Jun 2017
PMID: 28328045
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Abstract
Problem: Little is known about how infection and the response to inflammation affect the microRNA (miRNA) profile of the male reproductive tract. We hypothesized that expression of inflammatory-related miRNAs would be altered following immune activation of rat testis.
Method of study: Testis total RNA was purified from Sprague-Dawley rats 3 or 6 hours after receiving a 5 mg/kg intraperitoneal injection of bacterial lipopolysaccharide (LPS) and examined by qPCR using an 84-panel miRNA array.
Results: Five inflammatory-related miRNAs showed a greater than twofold down-regulation (P<.05) in the 3-hour group (rno-let-7f-5p, rno-miR-200c-3p, rno-miR-23a-3p, rno-miR-23b-3p, rno-miR-98-5p) and five from the 6-hour group (rno-miR-17-5p, rno-miR-19a-3p, rno-miR-34a-5p, rno-miR-34c-5p, rno-miR-449a-5p).
Conclusion: Review of the literature has revealed that these miRNAs also play important roles in the maintenance of fertility, formation and elimination of cancer, and development of the male reproductive tract. Further study will lead to a greater understanding of male reproductive immunology and related health issues.
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Details
- Title
- MicroRNAs downregulated following immune activation of rat testis
- Creators
- Mitchell I. Parker - Drexel UniversityMichael A. Palladino - Monmouth University
- Publication Details
- American journal of reproductive immunology (1989), v 77(6), e12673
- Publisher
- Wiley
- Number of pages
- 4
- Grant note
- Independent College Fund of New Jersey Bristol-Myers Squibb Foundation; Bristol-Myers Squibb Monmouth University School of Science Merck Co., Inc.; Merck & Company
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000403366400002
- Scopus ID
- 2-s2.0-85016044700
- Other Identifier
- 991020100052504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Reproductive Biology