Journal article
MicroRNAs, hepatitis C virus, and HCV/HIV-1 co-infection: new insights in pathogenesis and therapy
Viruses, v 4(11), pp 2485-2513
26 Oct 2012
PMID: 23202492
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
MicroRNAs (miRNAs) can exert a profound effect on Hepatitis C virus (HCV) replication. The interaction of HCV with the highly liver-enriched miRNA, miR-122 represents one such unique example of viruses having evolved mechanism(s) to usurp the host miRNA machinery to support viral life cycle. Furthermore, HCV infection can also trigger changes in the cellular miRNA profile, which may ultimately contribute to the outcome of viral infection. Accumulating knowledge on HCV-host miRNA interactions has ultimately influenced the design of therapeutic interventions against chronic HCV infection. The importance of microRNA modulation in Human Immunodeficiency Virus (HIV-1) replication has been reported, albeit only in the context of HIV-1 mono-infection. The development of HCV infection is dramatically influenced during co-infection with HIV-1. Here, we review the current knowledge on miRNAs in HCV mono-infection. In addition, we discuss the potential role of some miRNAs, identified from the analyses of public data, in HCV/HIV-1 co-infection.
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Details
- Title
- MicroRNAs, hepatitis C virus, and HCV/HIV-1 co-infection: new insights in pathogenesis and therapy
- Creators
- Archana Gupta - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA. ag434@drexel.eduGokul SwaminathanJulio Martin-GarciaSonia Navas-Martin
- Publication Details
- Viruses, v 4(11), pp 2485-2513
- Publisher
- MDPI; Switzerland
- Grant note
- R21 AI088423 / NIAID NIH HHS R21 AI098549 / NIAID NIH HHS R21 DK089314 / NIDDK NIH HHS R01 NS065727 / NINDS NIH HHS NS065727 / NINDS NIH HHS AI098549 / NIAID NIH HHS DK089314 / NIDDK NIH HHS NS061179 / NINDS NIH HHS AI088423 / NIAID NIH HHS R03 NS061179 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000311429900005
- Scopus ID
- 2-s2.0-84870626327
- Other Identifier
- 991014878335204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology