Journal article
Microbiology testing capacity and antimicrobial drug resistance in surgical-site infections: a post-hoc, prospective, secondary analysis of the FALCON randomised trial in seven low-income and middle-income countries
The Lancet global health
05 Sep 2024
Abstract
Surgical-site infection (SSI) is one of the most common health-care-associated infections, substantially contributing to antibiotic use. Targeted antibiotic prophylaxis to prevent SSIs and effective treatment are crucial to controlling antimicrobial resistance (AMR). This study aimed to describe the testing capacity and multidrug resistance (MDR) of SSI microorganisms in low-income and middle-income countries (LMICs).
This analysis included patients undergoing abdominal surgery in seven LMICs (Benin, Ghana, India, Mexico, Nigeria, Rwanda, and South Africa) as part of the FALCON randomised controlled trial. Wound swabs were collected from patients diagnosed with SSI, as per US Centers for Disease Control and Prevention (CDC) definition. Data on microorganism species and MDR, as per CDC and European Centre for Disease Prevention and Control definitions, were analysed alongside hospital-level data on local microbiological practices. An adjusted analysis was performed to identify perioperative factors associated with MDR. Testing capacity was assessed by the completion of swab testing in positively diagnosed SSIs.
Between Dec 10, 2018, and Sept 7, 2020, 5788 patients were recruited to the FALCON trial. 1163 patients were diagnosed with an SSI, of whom 905 (77·8%) received prophylactic antibiotics before surgery. In patients with SSIs, 935 of 1163 (80·4%) did not have a wound swab; 195 were from hospitals not performing swabs (15 hospitals) and 740 were from hospitals with capacity but no swab performed (35 hospitals). Of 228 patients swabbed, 200 (88·5%) had microorganisms detected. Escherichia coli (89 of 200, 37·9%) was the most common microorganism and 116 of 200 (58·0%) patients were not covered by the perioperative prophylactic antibiotic. MDR was found in 102 of 147 (69·4%) patients for whom data were available to determine MDR status. Adjusted analysis found that appropriate prophylactic antibiotic coverage (adjusted odds ratio 0·43, 95% CI 0·19–0·96) and regular availability of infection control teams (0·32, 0·11–0·93) were associated with a significant reduction in MDR.
Targeted perioperative antibiotic prophylaxis during contaminated abdominal surgery is insufficient in LMICs, with very few SSI organisms undergoing formal diagnosis. Expansion of testing capacity, development of local guidelines, and implementation of infection control teams could support the prevention of SSI through directed antibiotic prophylaxis, subsequently reducing the burden of MDR.
National Institute for Health and Care Research.
For the French and Spanish translations of the abstract see Supplementary Materials section.
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- Title
- Microbiology testing capacity and antimicrobial drug resistance in surgical-site infections: a post-hoc, prospective, secondary analysis of the FALCON randomised trial in seven low-income and middle-income countries
- Creators
- Aaron Oladipo AboderinSolomon AmfoabegyiAbimbola Temitayo AwopejuMichael Bahrami-HessariEmmanuel Isaac Acquah GarchieMartin GillAkosua KarikariAndrew KirbyOlufunmilola MakanjuolaBamidele MutiuAnthony Bassey OffiongPhilip Olayiwola OshunHisham Alhassan OsumanuAlex Owusu-OforiShereen Rachel VargheseLeslie Issa Adam-ZakariahAdemola Tolulope AdebanjoCelina Cuellar AguirreErica AkotoAliyu AminuRalph ArmahNeerav David AruldasAshish V ChoudhrieChristian Larbi CoompsonOkechukwu Hyginus EkwunifeMaria FourtounasSouliath LawaniArpit Jacob MathewAkhil PatelAdesoji O AdemuyiwaPollyanna HardyEmmy RunigamugaboPierre SodonougboHulrich BehanzinSosthène KangniGérard AgbotonLuke Aniakwo AdagrahEsther Adjei-AcquahAto Oppong AcquahJames AnkomahRegina AcquahKwame Gyambibi AddoDorcas Otuo AcheampongNii Armah Adu-AryeeFatao AbubakariAbraham TitigahFrank OwusuRaphael Adu-BrobbeyVivian AdobeaFrancis Atindaana AbantangaArun GauthamDimple BhattiEsther Daniel Mark JesudasonManisha AggarwalPhilip AlexanderAmos DasariRahul AlpheusHemanth KumarSubrat RaulWenceslao Ángeles BuenoReyes Cervantes OrtizIsaac Baltazar GomezClaudia Caballero CerdanMariana Barreto GalloRozana Reyes GamezIrani Durán SánchezLawal AbdullahiOpeoluwa AdesanyaMoruf AbdulsalamVictoria AdeleyeOchomma EgwuonwuAkeem AdelekeFrancis AdebayoGodwin ChiejinaOlukayode AbayomiLukman Abdur-RahmanJude EdeUba EzinneSalathiel KanyarukikoMoses DusabeAime Dieudonne HirwaGeorges BucyibarutaMary Augusta AdamsCheryl BirtlesZain AllyAbdus-sami AdewunmiJonathan CookJulia BrownAdewale O AdisaLawani IsmailAneel BhanguOmar OmarJoana FF SimoesElizabeth LiDaoud ChaudhrySamerah SaeedEleanor Margaret SpurringAzmina VerjeePamphile AssoutoDjifid Morel SetoCyrile KpangonRene AhossiBin Baaba Alhaji AlhassanVera AgyekumFrank Assah-AdjeiChristopher AsareJames AmoakoEnoch Appiah AkosaJane AcquayeFaisal AdjeiCletus BalluAmos BenninDarling Ramatu AbdulaiAlice HepzibahWilliam BhattiPriyadarshini K PaulParth DhamijaJosy ThomasPriya JacobAshish ChoudhrieNitin 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- Publication Details
- The Lancet global health
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Scopus ID
- 2-s2.0-85204650444
- Other Identifier
- 991021903271604721