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Microbubble-based Radiosensitization of Hepatocellular Carcinoma: Evaluation of Safety and Efficacy in a Phase II Randomized Trial
Journal article   Open access   Peer reviewed

Microbubble-based Radiosensitization of Hepatocellular Carcinoma: Evaluation of Safety and Efficacy in a Phase II Randomized Trial

Corinne E Wessner, Flemming Forsberg, Andrej Lyshchik, Patrick O'Kane, Kristen Bradigan, Ji-Bin Liu, Lauren J Delaney, Kevin Anton, Stephen R Topper, Jesse Civan, …
Radiology, v 316(3), e250083
01 Sep 2025
DOI: https://doi.org/10.1148/radiol.250083
PMID: 41025990
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://pmc.ncbi.nlm.nih.gov/articles/PMC12501628/View
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Abstract

Aged Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - radiotherapy Carcinoma, Hepatocellular - therapy Contrast Media Embolization, Therapeutic - methods Female Humans Liver Neoplasms - diagnostic imaging Liver Neoplasms - radiotherapy Liver Neoplasms - therapy Male Microbubbles - therapeutic use Middle Aged Prospective Studies Radiation-Sensitizing Agents - therapeutic use Treatment Outcome Yttrium Radioisotopes - therapeutic use
Background US contrast agents are gas-filled microbubbles that can be disrupted locally, such as via ultrasound-triggered microbubble destruction (UTMD), which can cause bioeffects that sensitize tumors to radiation. However, the efficacy and safety of UTMD combined with radiation therapy in participants with hepatocellular carcinoma (HCC) are unknown. Purpose To determine the treatment efficacy and safety of UTMD in participants with HCC receiving yttrium 90 ( Y) transarterial radioembolization (TARE). Materials and Methods In this prospective phase II clinical trial conducted from July 2017 to February 2024, participants with HCC scheduled for Y-TARE were randomly assigned to undergo Y-TARE with three UTMD sessions (treatment group) or Y-TARE alone (control group). The primary end point was treatment response evaluated at MRI or CT using modified Response Evaluation Criteria in Solid Tumors. Secondary end points included safety, overall survival, time to next treatment, rate of liver transplantation, and pathologic response in the event of transplantation. Changes in general laboratory values and vital signs were compared using unpaired and paired tests, survival and time to next treatment between groups were compared between groups using log-rank tests, and treatment response distribution was compared between groups using the Mann-Whitney test. Results The study sample consisted of 98 participants (mean age, 69 years ± 8.4 [SD]; 71 men). The safety analysis showed no evidence of a difference in vital signs before versus after the initial UTMD session in the treatment group (all ≥ .07). There was also no evidence of a difference in changes in general laboratory values from before to after treatment between the treatment and control groups (all ≥ .08). In the control group, 34% (17 of 50) of participants had stable disease, 22% (11 of 50) had partial response, and 44% (22 of 50) had complete response; in the treatment group, 4% (two of 48) had stable disease, 35% (17 of 48) had partial response, and 60% (29 of 48) had complete response. Thus, UTMD increased the proportion of participants who experienced complete or partial response by 30 percentage points (96% [46 of 48] vs 66% [33 of 50]; = .01). Overall survival was higher in the treatment group than in the control group (mortality hazard ratio, 0.51 [95% CI: 0.28, 0.95]; = .03). Conclusion Compared with only Y-TARE, adding microbubble-based radiosensitization via UTMD to Y-TARE in the treatment of HCC had similar safety, provided improved treatment response, and prolonged survival. ClinicalTrials.gov Identifier: NCT03199274 © RSNA, 2025

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Collaboration types
Domestic collaboration
Web of Science research areas
Radiology, Nuclear Medicine & Medical Imaging
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