Journal article
Microchimerism and scleroderma: an update
Current rheumatology reports, v 5(2), pp 154-159
Apr 2003
PMID: 12628047
Abstract
Microchimerism has been defined by the presence of a low number of circulating cells transferred from one individual to another. This transfer takes place naturally during pregnancy, between mother and fetus, or between fetuses in multigestational pregnancies. Furthermore, the establishment of microchimerism can also occur during blood transfusion, as well as during bone marrow and solid-organ transplants. Recently, microchimeric cells have been implicated in the pathogenesis of autoimmune diseases, particularly systemic sclerosis. Studies have demonstrated an increased presence of microchimeric cells in peripheral blood and tissues from patients with systemic sclerosis, and, more recently, microchimeric cells were demonstrated to be specifically activated and capable of recognizing patient human leukocyte antigens.
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15 citations in Scopus
Details
- Title
- Microchimerism and scleroderma: an update
- Creators
- Carol M Artlett - Thomas Jefferson University
- Publication Details
- Current rheumatology reports, v 5(2), pp 154-159
- Publisher
- Springer Nature
- Grant note
- R29 AR45399 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Scopus ID
- 2-s2.0-0038044586
- Other Identifier
- 991020200888104721