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Journal article
Microsecond-pulsed dielectric barrier discharge plasma stimulation of tissue macrophages for treatment of peripheral vascular disease
Physics of plasmas, v 22(12), pp 122005-122005
01 Dec 2015
PMID: 26543345
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Angiogenesis is the formation of new blood vessels from pre-existing vessels and normally occurs during the process of inflammatory reactions, wound healing, tissue repair, and restoration of blood flow after injury or insult. Stimulation of angiogenesis is a promising and an important step in the treatment of peripheral artery disease. Reactive oxygen species have been shown to be involved in stimulation of this process. For this reason, we have developed and validated a non-equilibrium atmospheric temperature and pressure short-pulsed dielectric barrier discharge plasma system, which can non-destructively generate reactive oxygen species and other active species at the surface of the tissue being treated. We show that this plasma treatment stimulates the production of vascular endothelial growth factor, matrix metalloproteinase-9, and CXCL 1 that in turn induces angiogenesis in mouse aortic rings in vitro. This effect may be mediated by the direct effect of plasma generated reactive oxygen species on tissue. (C) 2015 AIP Publishing LLC.
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Details
- Title
- Microsecond-pulsed dielectric barrier discharge plasma stimulation of tissue macrophages for treatment of peripheral vascular disease
- Creators
- V. Miller - Drexel UniversityA. Lin - Drexel UniversityF. Kako - Temple UniversityK. Gabunia - Temple UniversityS. Kelemen - Temple UniversityJ. Brettschneider - Drexel UniversityG. Fridman - Drexel UniversityA. Fridman - Drexel UniversityM. Autieri - Temple University
- Publication Details
- Physics of plasmas, v 22(12), pp 122005-122005
- Publisher
- American Institute of Physics
- Number of pages
- 5
- Grant note
- HL115575; HL117724 / National Heart Lung and Blood Institute of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01HL117724 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology Department Internal Research; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000367460400007
- Scopus ID
- 2-s2.0-84945263598
- Other Identifier
- 991019169655304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physics, Fluids & Plasmas