Journal article
Microstructural fatigue fracture behavior of glycated cortical bone
Medical & biological engineering & computing, v 61(11), pp 3021-3034
16 Aug 2023
PMID: 37582979
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The current study aims to simulate fatigue microdamage accumulation in glycated cortical bone with increased advanced glycation end-products (AGEs) using a phase field fatigue framework. We link the material degradation in the fracture toughness of cortical bone to the high levels of AGEs in this tissue. We simulate fatigue fracture in 2D models of cortical bone microstructure extracted from human tibias. The results present that the mismatch between the critical energy release rate of microstructural features (e.g., osteons and interstitial tissue) can alter crack initiation and propagation patterns. Moreover, the high AGEs content through the increased mismatch ratio can cause the activation or deactivation of bone toughening mechanisms under cyclic loading. The fatigue fracture simulations also show that the lifetime of diabetic cortical bone samples can be dependent on the geometry of microstructural features and the mismatch ratio between the features. Additionally, the results indicate that the trapped cracks in cement lines in the diabetic cortical microstructure can prevent further crack growth under cyclic loading. The present findings show that alterations in the materials heterogeneity of microstructural features can change the fatigue fracture response, lifetime, and fragility of cortical bone with high AGEs contents.
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Details
- Title
- Microstructural fatigue fracture behavior of glycated cortical bone
- Creators
- Ebrahim Maghami - Drexel UniversityAhmad Najafi - Drexel University
- Publication Details
- Medical & biological engineering & computing, v 61(11), pp 3021-3034
- Publisher
- Springer Nature
- Number of pages
- 14
- Grant note
- CMMI-2143422 / National Science Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:001049086900001
- Scopus ID
- 2-s2.0-85168128001
- Other Identifier
- 991020924046104721
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- Web of Science research areas
- Computer Science, Interdisciplinary Applications
- Engineering, Biomedical
- Mathematical & Computational Biology
- Medical Informatics