Journal article
Microtubule Inhibitors and Cardiotoxicity
Current oncology reports, v 23(3), 30
Mar 2021
PMID: 33582937
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cancer and heart disease are the leading causes of mortality in the USA. Advances in cancer therapies, namely, the development and use of chemotherapeutic agents alone or in combination, are becoming increasingly prevalent.
Many chemotherapeutic agents have been associated with adverse cardiovascular manifestations. The mechanisms of these sequelae remain incompletely understood. In particular, microtubule inhibitor (MTI) agents have been related to the development of heart failure, myocardial ischemia, and conduction abnormalities. At present, there are no guidelines for patients undergoing MTI therapy as it pertains to both preventative and mitigatory strategies for cardiovascular complications. We conducted a literature review focusing on content related to the use of MTIs and their effect on the cardiovascular system. MTIs have been associated with various forms of cardiotoxicity, and fatal cardiotoxicities are rare. The most well-described cardiotoxicities are brady- and tachyarrhythmias. The co-administration of anthracycline-based agents with MTIs can increase the risk of cardiotoxicity.
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Details
- Title
- Microtubule Inhibitors and Cardiotoxicity
- Creators
- Amogh M Joshi - Lehigh Valley Hospital-PoconoGeorge S Prousi - University of South CarolinaChristopher Bianco - West Virginia UniversityMidhun Malla - West Virginia UniversityAvirup Guha - Western University of Health SciencesMahek Shah - Thomas Jefferson UniversitySherry-Ann Brown - Medical College of WisconsinBrijesh Patel - West Virginia University
- Publication Details
- Current oncology reports, v 23(3), 30
- Publisher
- Springer Nature
- Grant note
- U54 GM104942 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000620509800003
- Scopus ID
- 2-s2.0-85100832387
- Other Identifier
- 991022160422604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology