Journal article
Microtubule transport in the axon: Re-thinking a potential role for the actin cytoskeleton
The Neuroscientist (Baltimore, Md.), v 12(2)
Apr 2006
PMID: 16514008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Microtubules are transported down the axon as short pieces by molecular motor proteins. One popular idea is that these microtubules are transported by forces generated against the actin cytoskeleton. The motor for such transport is thought to be cytoplasmic dynein. Here, the authors review this model and discuss recent studies that sought to test it. These studies suggest that the model is valid but incomplete. Microtubule transport is bidirectional and can utilize either actin filaments or longer microtubules as a substrate in the anterograde direction but only longer microtubules in the retrograde direction. Cytoplasmic dynein is one participating motor but not the only one. The authors speculate that the category of anterograde microtubule transport that involves actin filaments may have specialized functions. The relevant forces that transport short microtubules may also be crucial for the manner by which the longer immobile microtubules interact with actin filaments during events such as axonal retraction and growth cone turning.
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Details
- Title
- Microtubule transport in the axon: Re-thinking a potential role for the actin cytoskeleton
- Creators
- Kenneth A Myers - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USAYan HeThomas P HasakaPeter W Baas
- Publication Details
- The Neuroscientist (Baltimore, Md.), v 12(2)
- Publisher
- Sage; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000236108800010
- Scopus ID
- 2-s2.0-33646671227
- Other Identifier
- 991014878156404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences